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Dimitri from Paris: A Night at the Playboy Mansion (2004) IMDB Page. 2011ä¹´4æ¥10æ22æ¥.Down syndrome is one of the most common genetic conditions and is associated with severe mental retardation, with deafness and specific facial features. From a clinical perspective, one of the most challenging aspects of this condition is its variable severity and high rate of cognitive regression, which can lead to death in young children. In fact, most cases of Down syndrome are sporadic; however, some cases have been reported to have a genetic cause. The discovery of pathogenic mechanisms of DS was based on the identification of genes that carry mutations, such as the HTR6 gene. Now that most cases of Down syndrome result from the inheritance of trisomy 21, the predisposition to DS is thought to be of maternal origin. In the present study, we used the mouse model of Down syndrome, Ts65Dn, which shows chromosomal trisomy 21 and an altered expression pattern for several genes, including genes for brain-derived neurotrophic factor (BDNF). In addition, the cellular mechanisms involved in the altered expression of BDNF in Ts65Dn are not yet completely known. Our preliminary results showed that Ts65Dn mice also exhibit cognitive impairments. Therefore, we sought to determine the possible alterations in the cellular and molecular mechanisms involved in the differential expression of BDNF in Ts65Dn mice. Here, we focus on the possible roles of microRNAs in this context.
BARREL.
: Barrel fields
BDNF.
: Brain-derived neurotrophic factor
CASK.
: Calcium/calmodulin-dependent serine protein kinase
DBN.
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/**
* Autogenerated by Thrift
*
* DO NOT EDIT UNLESS YOU ARE SURE THAT YOU KNOW WHAT YOU ARE DOING
* @generated
*/
#pragma once
#include
#include
#include
#include
namespace cereal {
namespace detail {
class Metadata_types {
virtual ~Metadata_types() {};
typedef std::vector StringVector;
typedef std::map IntegerMap;
void init() {
::cereal::detail::InitializeRegistrations();
};
::cereal::detail::MetadataRegistration* registerProtocol(::cereal::detail::TMetadataProtocol*);
::cereal::detail::MetadataRegistration* registerMessageName(std::string);
::cereal::detail::MetadataRegistration* registerMessageName(const char*);
::cereal::detail::MetadataRegistration* registerMessageName(const char*, int);
::cereal::detail::MetadataRegistration* registerMessageName(const char*, int, bool);
::cereal::detail::MetadataRegistration* registerMessageName(::cereal::detail::TMetadataProtocol*, std::string, const char*, int);
::cereal::detail::MetadataRegistration* registerMessageName(::cereal::detail::TMetadataProtocol*, std::string, const char*, int, bool);
::cereal::detail::MetadataRegistration* registerMessageName(::cereal::detail::TMetadataProtocol*, ::cereal::detail::TMetadataProtocol*);
::cereal::detail::MetadataRegistration* registerMessageName(::cereal::detail::TMetadataProtocol*, std::string, ::cereal::detail::
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